Glipizide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). An Overview of Metformin and Contrast Medium Metformin (Glucophage ®) is a prescription medication licensed to treat type 2 diabetes. Due to an increased risk of a dangerous side effect called lactic acidosis, metformin should be temporarily stopped in people undergoing procedures involving contrast medium. Usually, the first diabetes medication that your doctor may prescribe is Metformin. However, many times, Glipizide is a popular choice for doctors to prescribe because many patients find that their bodies tolerate Glipizide better than Metformin. Glipizide is a diabetes drug designed to help your body process sugar. In a normal person, the pancreas helps the body store excess sugar by releasing insulin in the proper amounts to give you energy. Diabetics do not store sugar properly, however, and instead, sugar remains in the bloodstream. The most common side-effects of Metformin are feeling sick, diarrhea and abdominal pain. It is best to take metformin after a meal to decrease stomach side effects including diarrhea. As with any medication, it is possible to overdose on metformin. Some of the effects of a metformin overdose may include low blood sugar or lactic acidosis. For the treatment of type 2 diabetes mellitus as an adjunct to diet and exercise to improve glycemic control. Metformin is used alone or with other medications, including insulin, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). It's unfortunate no one, who has taken these medicines, has responded. I must say it doesn't look like many people would have that sort of reaction with both metformin and glipizide. Metformin may rarely cause a serious, life-threatening condition called lactic acidosis. Tell your doctor if you have kidney disease. Your doctor will probably tell you not to take metformin.